To support its new vision to build a national Culture of Health, Robert Wood Johnson Foundation has launched Evidence for Action: Investigator-Initiated Research to Build a Culture of Health (“Evidence for Action”). Evidence for Action aims to develop the evidence base needed to enable our society to lead healthier lives, providing individuals, organizations, communities, policymakers, and researchers with the empirical evidence needed to address the key determinants of health. The program will also support efforts to assess outcomes and set priorities for action by funding creative, rigorous research on the impact of innovative programs, policies and partnerships on health and well-being, and on novel approaches to measuring health determinants and outcomes. Proposals are being accepted on a rolling basis with a required letter of intent and invitation for full proposal. The initiative will award $2.2 million annually with the expectation of supporting five to 12 awards each year for periods of up to 30 months. Awards will be made to organizations, not to individuals.